MPTP NEUROTOXICITY SYNDROMES
\ˌɛmpˌiːtˌiːpˈiː njˌuːɹə͡ʊtəksˈɪsɪti sˈɪndɹə͡ʊmz], \ˌɛmpˌiːtˌiːpˈiː njˌuːɹəʊtəksˈɪsɪti sˈɪndɹəʊmz], \ˌɛ_m_p_ˌiː_t_ˌiː_p_ˈiː n_j_ˌuː_ɹ_əʊ_t_ə_k_s_ˈɪ_s_ɪ_t_i s_ˈɪ_n_d_ɹ_əʊ_m_z]\
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A condition caused by the neurotoxin 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. MPTP causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36 (2):250-8)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.