NEOCARZINOSTATIN
\nˈiːə͡ʊkˌɑːzɪnˌɒstɐtˌɪn], \nˈiːəʊkˌɑːzɪnˌɒstɐtˌɪn], \n_ˈiː__əʊ_k_ˌɑː_z_ɪ_n_ˌɒ_s_t_ɐ_t_ˌɪ_n]\
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An antitumor isolate from the culture filtrate of the F-41 variant of Streptomyces carzinostaticus. It is a protein of known amino acid sequence with a molecular weight of approximately 11,500 and possessing a regulatory function on the metabolism of DNA. In this process, that is first an inhibition of DNA biosynthesis followed by the degradation of DNA, zinostatin functions in a manner analogous to that of the much higher molecular weight antibiotic MITOMYCIN. Zinostatin is also a potent cytostatic agent active against gram-positive organisms.
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.