MK0791
\ˌɛmkˈe͡ɪ zˈi͡əɹə͡ʊsˈɛvənnˈa͡ɪnwˈɒn], \ˌɛmkˈeɪ zˈiəɹəʊsˈɛvənnˈaɪnwˈɒn], \ˌɛ_m_k_ˈeɪ z_ˈiə_ɹ_əʊ_s_ˈɛ_v_ə_n__n_ˈaɪ_n_w_ˈɒ_n_]\
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A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukeotriene E4.
By DataStellar Co., Ltd
