NEUTROPHIL ACTIVATING PEPTIDE
\njˈuːtɹəfˌɪl ˈaktɪvˌe͡ɪtɪŋ pˈɛpta͡ɪd], \njˈuːtɹəfˌɪl ˈaktɪvˌeɪtɪŋ pˈɛptaɪd], \n_j_ˈuː_t_ɹ_ə_f_ˌɪ_l ˈa_k_t_ɪ_v_ˌeɪ_t_ɪ_ŋ p_ˈɛ_p_t_aɪ_d]\
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A cytokine that activates neutrophils and attracts neutrophils and T-lymphocytes. It is released by several cell types including monocytes, macrophages, T-lymphocytes, fibroblasts, endothelial cells, and keratinocytes by an inflammatory stimulus. IL-8 is a member of the beta-thromboglobulin superfamily and structurally related to platelet factor 4.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.