HAGEMAN FACTOR FRAGMENTS
\hˈe͡ɪd͡ʒmən fˈaktə fɹˈaɡmənts], \hˈeɪdʒmən fˈaktə fɹˈaɡmənts], \h_ˈeɪ_dʒ_m_ə_n f_ˈa_k_t_ə f_ɹ_ˈa_ɡ_m_ə_n_t_s]\
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Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
By DataStellar Co., Ltd
Nearby Words
- hagdon
- hagedorn needle
- hagedorn's needle
- hagedorn's needle.
- hageman factor
- Hageman Factor Fragments
- hageman trait
- hagenia abyssinica
- hagerite, the
- hagerstown
- hagfish