MK791
\ˌɛmkˈe͡ɪ sˈɛvənhˈʌndɹədən nˈa͡ɪntiwˈɒn], \ˌɛmkˈeɪ sˈɛvənhˈʌndɹədən nˈaɪntiwˈɒn], \ˌɛ_m_k_ˈeɪ s_ˈɛ_v_ə_n_h_ˈʌ_n_d_ɹ_ə_d_ə_n n_ˈaɪ_n_t_i_w_ˈɒ_n]\
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A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukeotriene E4.
By DataStellar Co., Ltd
