MK803
\ˌɛmkˈe͡ɪ ˈe͡ɪthˈʌndɹədən θɹˈiː], \ˌɛmkˈeɪ ˈeɪthˈʌndɹədən θɹˈiː], \ˌɛ_m_k_ˈeɪ ˈeɪ_t_h_ˈʌ_n_d_ɹ_ə_d_ə_n θ_ɹ_ˈiː]\
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A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
By DataStellar Co., Ltd
