PLURONIC L81
\plʊ͡əɹˈɒnɪk ˈɛl ˈe͡ɪtiwˈɒn], \plʊəɹˈɒnɪk ˈɛl ˈeɪtiwˈɒn], \p_l_ʊə_ɹ_ˈɒ_n_ɪ_k ˈɛ_l ˈeɪ_t_i_w_ˈɒ_n]\
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A nonionic polyoxyethylene-polyoxypropylene block co-polymer with the general formula HO (C2H4O)a (-C3H6O)b (C2H4O)aH. It is available in different grades which vary from liquids to solids. It is used as an emulsifying agent, solubilising agent, surfactant, and wetting agent for antibiotics. Poloxamer is also used in ointment and suppository bases and as a tablet binder or coater. (Martindale The Extra Pharmacopoeia, 31st ed)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.