CLONIDINE
\klˈɒnɪdˌiːn], \klˈɒnɪdˌiːn], \k_l_ˈɒ_n_ɪ_d_ˌiː_n]\
Definitions of CLONIDINE
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an antihypertensive (trade name Catapres) that can be administered orally or via transdermal patches
By Princeton University
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an antihypertensive (trade name Catapres) that can be administered orally or via transdermal patches
By DataStellar Co., Ltd
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An alpha-2 adrenergic agonist that crosses the blood-brain barrier. Clonidine acts centrally by reducing sympathetic tone, resulting in a fall in diastolic and systolic blood pressure and a reduction in heart rate. It also acts peripherally, and this peripheral activity may be responsible for the transient increase in blood pressure seen during rapid intravenous administration. (From Martindale, the Extra Pharmacopoeia, 30th ed, p350)
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.