SYSTEMIC INFLAMMATORY RESPONSE SYNDROME
\sɪstˈɛmɪk ɪnflˈamətəɹˌi ɹɪspˈɒns sˈɪndɹə͡ʊm], \sɪstˈɛmɪk ɪnflˈamətəɹˌi ɹɪspˈɒns sˈɪndɹəʊm], \s_ɪ_s_t_ˈɛ_m_ɪ_k ɪ_n_f_l_ˈa_m_ə_t_ə_ɹ_ˌi ɹ_ɪ_s_p_ˈɒ_n_s s_ˈɪ_n_d_ɹ_əʊ_m]\
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A systemic response to infection, defined as hypothermia or hyperthermia, tachycardia, tachypnea, a clinically evident focus of infection or positive blood cultures, one or more end organs with either dysfunction or inadequate perfusion, cerebral dysfunction, hypoxemia, increased plasma lactate or unexplained metabolic acidosis, and oliguria. It is one of the most common causes of adult respiratory distress syndrome (RESPIRATORY DISTRESS SYNDROME, ADULT). (Segen, Dictionary of Modern Medicine, 1992) While usually related to infection, it can also be associated with noninfectious insults such as trauma, burns, pancreatitis. (JAMA 1995;273 (2):155-6)
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