CHOLERA EXOTOXIN
\kˈɒləɹəɹ ɛɡzˈɒtəksˌɪn], \kˈɒləɹəɹ ɛɡzˈɒtəksˌɪn], \k_ˈɒ_l_ə_ɹ_ə_ɹ ɛ_ɡ_z_ˈɒ_t_ə_k_s_ˌɪ_n]\
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The enterotoxin from Vibrio cholerae. It is a protein that consists of two major components, the heavy (H) or A peptide and the light (L) or B peptide or choleragenoid. The B peptide anchors the protein to intestinal epithelial cells, while the A peptide, enters the cytoplasm, and activates adenylate cyclase, and production of cAMP. Increased levels of cAMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
By DataStellar Co., Ltd
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