HUTCHINSON GILFORD SYNDROME
\hˈʌt͡ʃɪnsən ɡˈɪlfəd sˈɪndɹə͡ʊm], \hˈʌtʃɪnsən ɡˈɪlfəd sˈɪndɹəʊm], \h_ˈʌ_tʃ_ɪ_n_s_ə_n ɡ_ˈɪ_l_f_ə_d s_ˈɪ_n_d_ɹ_əʊ_m]\
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An abnormal congenital condition characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.
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Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.