NITRIC OXIDE SYNTHASE
\nˈa͡ɪtɹɪk ˈɒksa͡ɪd sˈɪnθe͡ɪs], \nˈaɪtɹɪk ˈɒksaɪd sˈɪnθeɪs], \n_ˈaɪ_t_ɹ_ɪ_k ˈɒ_k_s_aɪ_d s_ˈɪ_n_θ_eɪ_s]\
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An enzyme that catalyzes the conversion of L-arginine, NADPH, and oxygen to citrulline, nitric oxide, and NADP+. The enzyme found in brain, but not that induced in lung or liver by endotoxin, requires calcium. (From Enzyme Nomenclature, 1992) EC 1.14.13.39.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.