PIGAULT-LEBRUN

\pˈɪɡɒltlˈɛbɹʌn], \pˈɪɡɒltlˈɛbɹʌn], \p_ˈɪ_ɡ_ɒ_l_t_l_ˈɛ_b_ɹ_ʌ_n]\
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1910 - Warner's dictionary of authors ancient and modern
By Charles Dudley Warner

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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