ANTHRACYCLINE ANTIBIOTICS
\ˈanθɹɐsˌa͡ɪkla͡ɪn ˌantɪba͡ɪˈɒtɪks], \ˈanθɹɐsˌaɪklaɪn ˌantɪbaɪˈɒtɪks], \ˈa_n_θ_ɹ_ɐ_s_ˌaɪ_k_l_aɪ_n ˌa_n_t_ɪ_b_aɪ_ˈɒ_t_ɪ_k_s]\
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Antibiotics which have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to a sugar molecule. These antibiotics have potent antineoplastic activity. The two best known members of this group are daunorubicin and doxorubicin. Since these agents intercalate with DNA, many DNA functions are adversely affected. Futhermore they interact with cell membranes thereby altering their functions and also generate hydrogen peroxide and hydroxy radicals which are highly destructive to cells.
By DataStellar Co., Ltd
Word of the day
Snake's-head
- Guinea-hen flower; -- so called in England because its spotted petals resemble the scales of a snake's head.