CONRAD MALTE-BRUN

\kˈɒnɹad mˈɒltbɹˈʌn], \kˈɒnɹad mˈɒltbɹˈʌn], \k_ˈɒ_n_ɹ_a_d m_ˈɒ_l_t_b_ɹ_ˈʌ_n]\
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1910 - Warner's dictionary of authors ancient and modern
By Charles Dudley Warner

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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