EXAMEN RIGOROSUM

\ɛɡzˈe͡ɪmɛn ɹˈɪɡɔːɹˌɒsəm], \ɛɡzˈe‍ɪmɛn ɹˈɪɡɔːɹˌɒsəm], \ɛ_ɡ_z_ˈeɪ_m_ɛ_n ɹ_ˈɪ_ɡ_ɔː_ɹ_ˌɒ_s_ə_m]\
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1846 - Medical lexicon: a dictionary of medical science
By Robley Dunglison

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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