JB11
\d͡ʒˌe͡ɪbˈiː ɪlˈɛvən], \dʒˌeɪbˈiː ɪlˈɛvən], \dʒ_ˌeɪ_b_ˈiː_ ɪ_l_ˈɛ_v_ə_n]\
Sort: Oldest first
-
A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against Pneumocystis carinii pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.