MANTLE ZONE LYMPHOMA
\mˈantə͡l zˈə͡ʊn lɪmfˈə͡ʊmə], \mˈantəl zˈəʊn lɪmfˈəʊmə], \m_ˈa_n_t_əl z_ˈəʊ_n l_ɪ_m_f_ˈəʊ_m_ə]\
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A rare form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t (11;14) translocation resulting in overexpression of the cyclin D1 gene (GENES, BCL-1).
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.