TESTOSTERONE SULFATE
\tɛstˈɒstəɹˌə͡ʊn sˈʌlfe͡ɪt], \tɛstˈɒstəɹˌəʊn sˈʌlfeɪt], \t_ɛ_s_t_ˈɒ_s_t_ə_ɹ_ˌəʊ_n s_ˈʌ_l_f_eɪ_t]\
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The major androgenic hormone produced by the interstitial (Leydig) cells of the testes in response to stimulation by the luteinizing hormone of the anterior pituitary. It regulates gonadotropic secretion and wolffian duct differentiation, and stimulates skeletal muscle. It is also responsible for other male characteristics and spermatogenesis after its conversion to dihydrotestosterone. In addition testosterone possesses protein anabolic properties, and it is converted to estradiol in peripheral tissue. (From Dorland, 28th ed)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.