TRIMETHOPRIM
\tɹˈa͡ɪmɪθˌɒpɹɪm], \tɹˈaɪmɪθˌɒpɹɪm], \t_ɹ_ˈaɪ_m_ɪ_θ_ˌɒ_p_ɹ_ɪ_m]\
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A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
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