DEMETHYL EPIPODOPHYLLOTOXIN THENYLIDINE GLUCOSIDE
\dˈɛmiːθˌa͡ɪl ˈɛpɪpˌɒdəfˌɪlətˌɒksɪn θˈɛnɪlˌɪdiːn ɡlˈuːkəsˌa͡ɪd], \dˈɛmiːθˌaɪl ˈɛpɪpˌɒdəfˌɪlətˌɒksɪn θˈɛnɪlˌɪdiːn ɡlˈuːkəsˌaɪd], \d_ˈɛ_m_iː_θ_ˌaɪ_l ˈɛ_p_ɪ_p_ˌɒ_d_ə_f_ˌɪ_l_ə_t_ˌɒ_k_s_ɪ_n θ_ˈɛ_n_ɪ_l_ˌɪ_d_iː_n ɡ_l_ˈuː_k_ə_s_ˌaɪ_d]\
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A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
By DataStellar Co., Ltd
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