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Definition of epistle : 1. A writing directed or sent to a person or persons; a written communication; a letter; - applied usually to formal, didactic, or elegant letters.
2. One of the letters in the New Testament which were addressed to their Christian brethren by Apostles.
3. To write; to communicate in a letter or by writing.

Synonyms:

enclosure, the Old Testament, Holy Writ, words, the Good Book, circular, memo, biblical, cover letter, memorandum, gospel, billet-doux, dead letter, air letter, the Bible, the Holy Bible, the New Testament, chain letter, OT, missive, Dear John letter

letter, acknowledgment, post, line, note, postcard, answer, correspondence, reply

communication, announcement, information, flash, news, message, rumor, notice, bulletin, dispatch, release, statement, account, gossip, report

Usage examples:

• Then we shall see and believe from the Epistle what effect the knowledge of it ought to have upon our own souls, and hearts, and daily conduct. - "Sermons on National Subjects", Charles Kingsley.
• He was waving the epistle on high. - "The Sherrods", George Barr McCutcheon.
• She was, therefore, surprised when a second epistle was put into her hands, dated the day succeeding that on which she supposed Mr. Graham's party to have left the country. - "The Lamplighter", Maria S. Cummins.