HMWK
\ˌe͡ɪt͡ʃˌɛmdˌʌbə͡ljˌuːkˈe͡ɪ], \ˌeɪtʃˌɛmdˌʌbəljˌuːkˈeɪ], \ˌeɪ_tʃ_ˌɛ_m_d_ˌʌ_b_əl_j_ˌuː_k_ˈeɪ]\
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A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)
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