IRREVERSIBLE COMA
\ɪɹɪvˈɜːsəbə͡l kˈə͡ʊmə], \ɪɹɪvˈɜːsəbəl kˈəʊmə], \ɪ_ɹ_ɪ_v_ˈɜː_s_ə_b_əl k_ˈəʊ_m_ə]\
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A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
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