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Definition of sedative : 1. A remedy which allays irritability and irritation, and irritative activity or pain.
2. allaying irritability and irritation; assuaging pain.
3. Tending to calm, moderate, or tranquilize

Synonyms:

tranquilising, pacifying, depressant, tranquilizing, downer, somnific, slumberous, lulling, calming, somniferous, sedative drug, remedial, somnolent, opiate, anesthetic, quieting, antidote, soporific, soothing, comforting, tranquillising, antacid, amphetamine, narcotic, awareness, anabolic steroid, analgesic, relaxing, anticoagulant, ataractic, tranquillizing, antibiotic, somnifacient, sleepy, antidepressant, dreamy, anaesthetic, hypnotic, ataraxic

Usage examples:

• " And fix up a sedative to keep him quiet for not less than four nor more than six hours. - "Null-ABC", Henry Beam Piper and John Joseph McGuire.
• Her unusual brilliancy of imagination, unaccompanied by any sedative qualities, was one explanation of her character. - "Guide to the Kindergarten and Intermediate Class and Moral Culture of Infancy.", Elizabeth P. Peabody Mary Mann.
• She took the nerve tonic diligently, but it failed to act as a sedative to her fears. - "The Early Short Fiction of Edith Wharton, Part 2 (of 10)", Edith Wharton.