REV GENE PRODUCT
\ɹˈɛv d͡ʒˈiːn pɹˈɒdʌkt], \ɹˈɛv dʒˈiːn pɹˈɒdʌkt], \ɹ_ˈɛ_v dʒ_ˈiː_n p_ɹ_ˈɒ_d_ʌ_k_t]\
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Trans-acting nuclear proteins whose functional expression are required for HIV viral replication. Specifically, the rev gene products are required for processing and translation of the HIV gag and env mRNAs, and thus rev regulates the expression of the viral structural proteins. rev can also regulate viral regulatory proteins. A cis-acting antirepression sequence (CAR) in env, also known as the rev-responsive element (RRE), is responsive to the rev gene product. rev is short for regulator of virion.
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.