DISSEMINATED NEURODERMATITIS
\dɪsˈɛmɪnˌe͡ɪtɪd njˌuːɹə͡ʊdəmɐtˈa͡ɪtɪs], \dɪsˈɛmɪnˌeɪtɪd njˌuːɹəʊdəmɐtˈaɪtɪs], \d_ɪ_s_ˈɛ_m_ɪ_n_ˌeɪ_t_ɪ_d n_j_ˌuː_ɹ_əʊ_d_ə_m_ɐ_t_ˈaɪ_t_ɪ_s]\
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A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.