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Definition of vacuole : A small air cell, or globular space, in the interior of organic cells, either containing air, or a pellucid watery liquid, or some special chemical secretions of the cell protoplasm.

Usage examples:

• When they are sown upon water, one sees at the end of some hours the protoplasm divided by very fine lines, and each of the parts furnished with a small central vacuole. - "Fungi: Their Nature and Uses", Mordecai Cubitt Cooke.
• The ripe endospore is a thick, smooth, colourless membrane, composed of cellulose containing a bed of finely granulated protoplasm, which surrounds a great central vacuole. - "Fungi: Their Nature and Uses", Mordecai Cubitt Cooke.