VITAMIN A ALDEHYDE
\vˈɪtəmɪn ɐ ˈaldɪhˌa͡ɪd], \vˈɪtəmɪn ɐ ˈaldɪhˌaɪd], \v_ˈɪ_t_ə_m_ɪ_n ɐ ˈa_l_d_ɪ_h_ˌaɪ_d]\
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A carotenoid constituent of visual pigments. It is the oxidized form of retinol which functions as the active component of the visual cycle. It is bound to the protein opsin forming the complex rhodopsin. When stimulated by visible light, the retinal component of the rhodopsin complex undergoes isomerization at the 11-position of the double bond to the cis-form; this is reversed in "dark" reactions to return to the native trans-configuration.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.