chafe, lassitude, rub, fray, scratch, tiredness, prostration, collapse, weariness, enervation, burnout, exhaustion, fret.
She turned to Bob with a question: " Mrs. Carroll 'n Miss Sydney- are they wore to a frazzle
takin' care o' him?"
Was it done to a frazzle,
turkey- trotting with all the chaperons?
She's worn out, nerves frayed to a frazzle.