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Definition of manacle : 1. A handcuff; a shackle for the hand or wrist; - usually in the plural.
2. To put handcuffs or other fastening upon, for confining the hands; to shackle; to confine; to restrain from the use of the limbs or natural powers.

Synonyms:

interference, hunger strike, bracelet, stumbling block, bar, crimp, embarrassment, trammel, restraint, tie up, obstacle, fetters, whomp, cuffs, cuff, holdback, drag, ligature, bind, compound, conjugal visit, free, leg irons, deterrent, gag, hurdle, clog, balk, lights out, handlock, obstruction, band, hobble, gyve, truss, handcuffs, stop, cramp, chains, chain, yoke, impediment, handicap, block, hindrance, bond, iron, inhibition, let, shackles, turnup

imprison (part of speech: verb)

impound, imprison, fetter, condemn, incarcerate, sentence, lock up

prison (part of speech: noun)

handcuff, coop, collar, reform school, cooler, jailhouse, cage, jail, penal colony, pillory, pen, reformatory, harness, tether, irons, jug, brig, bridle, dungeon, pound, prison, fence, penitentiary, stronghold, keep, vise, San Quentin, shackle, stockade, confine, lockup, straight jacket, pinion, oubliette, Bastille, cell, gaol, Alcatraz

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