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Definition of handcuff : 1. A fastening, consisting of an iron ring around the wrist, usually connected by a chain with one on the other wrist; a manacle; - usually in the plural.
2. To apply handcuffs to; to manacle.

Synonyms:

whomp, iron, handcuffs, free, handlock, bond, restraint, gyve, chain, hobble, turnup, cuff, cuffs

impound, imprison, fetter, condemn, incarcerate, sentence, lock up

harness, coop, collar, reform school, cooler, jug, cage, jailhouse, penal colony, pillory, pen, reformatory, irons, tether, jail, keep, brig, bridle, dungeon, pound, prison, fence, penitentiary, stronghold, lockup, vise, San Quentin, shackle, stockade, confine, manacle, straight jacket, pinion, oubliette, Bastille, cell, gaol, Alcatraz

Usage examples:

• I told him we would walk to the next village, where he could get the pole mended; and, as I found that he was preparing to handcuff them together, I assured him that I would be answerable for the safety of all the prisoners. - "Memoirs of Henry Hunt, Esq. Volume 3", Henry Hunt.
• The handcuff grows taut on my wrist, and I follow the sheriff into the waiting carriage. - "Prison Memoirs of an Anarchist", Alexander Berkman.
• " This" meant that a handcuff was snapped round my right wrist, and its fellow, connected with it by a chain, round Harris's left. - "The Red Symbol", John Ironside.