MYC ONCOGENES
\mˈɪk ˈɒnkə͡ʊd͡ʒˌiːnz], \mˈɪk ˈɒnkəʊdʒˌiːnz], \m_ˈɪ_k ˈɒ_n_k_əʊ_dʒ_ˌiː_n_z]\
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Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8.
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