RETROBULBAR NEURITIDES
\ɹˌɛtɹə͡ʊbˈʌlbɑː njˈuːɹɪtˌa͡ɪdz], \ɹˌɛtɹəʊbˈʌlbɑː njˈuːɹɪtˌaɪdz], \ɹ_ˌɛ_t_ɹ_əʊ_b_ˈʌ_l_b_ɑː n_j_ˈuː_ɹ_ɪ_t_ˌaɪ_d_z]\
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Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as MULTIPLE SCLEROSIS, infections, and granulomatous diseases. Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (Marcus-Gunn pupil), and in some instances optic disc hyperemia and swelling. Inflammation may occur in the portion of the nerve within the globe (neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis).
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.