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Definition of aggravation : 1. An extrinsic circumstance or accident which increases the guilt of a crime or the misery of a calamity.
2. Exaggerated representation.
3. Provocation; irritation.
4. The act of aggravating, or making worse; - used of evils, natural or moral; the act of increasing in severity or heinousness; something additional to a crime or wrong and enhancing its guilt or injurious consequences.

Synonyms:

innervation, difficulty, botheration, besetment, feelings, irritant, incitement, affliction, peeve, discomfort, temper, nuisance, pain, incitation, worry, plague, excitation, annoying, exaggeration

exacerbation, annoyance, harassment, provocation, pique, petulance, bother, perturbation, resentment, bedevilment, arousal, exasperation, trouble, enragement, vexation, inflammation, scorn, virulence, discomposure, disturbance, indignation, ire

distressfulness, offensiveness, torture, severity, unpleasantness, cruelty, annoyingness, misery, torment, ache, uncomfortableness, hurtfulness, odiousness, grievousness, agony, oppressiveness, arduousness, soreness, irritation, bitterness, irksomeness, woefulness, anguish, acuteness, painfulness

Usage examples:

• For where ungodly people do dwell together, they being a snare and stumbling- block one to another by their practices, they must needs be a torment one to another, and an aggravation of each other's damnation. - "The Works of John Bunyan Volume 3", John Bunyan.
• Pressure on the popliteal vessels is a serious aggravation of the injury, and adds greatly to the difficulties of treatment. - "Manual of Surgery Volume Second: Extremities--Head--Neck. Sixth Edition.", Alexander Miles Alexis Thomson.
• To- day, to create aggravation, it is at least one good half- hour later than usual. - "Molly Bawn", Margaret Wolfe Hamilton.