CENTROTEMPORAL EPILEPSIES
\sˈɛntɹə͡ʊtmpəɹə͡l ˈɛpɪlˌɛpsɪz], \sˈɛntɹəʊtmpəɹəl ˈɛpɪlˌɛpsɪz], \s_ˈɛ_n_t_ɹ_əʊ_t_m_p_ə_ɹ_əl ˈɛ_p_ɪ_l_ˌɛ_p_s_ɪ_z]\
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An autosomal dominant inherited partial epilepsy syndrome with onset between age 3 and 13 years. Seizures are characterized by PARESTHESIA and tonic or clonic activity of the lower face associated with drooling and dysarthria. The episodes tend to occur at night and may become secondarily generalized. In most cases, affected children are neurologically and developmentally normal. The electroencephalogram shows characteristic high-voltage sharp waves over the central temporal regions, which are more prominent during drowsiness and sleep. In general, seizures do not continue beyond mid-adolescence. (From Epilepsia 1998 39;Suppl 4:S32-S41)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.