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Definition of weakness : 1. That which is a mark of lack of strength or resolution; a fault; a defect.
2. The quality or state of being weak; want of strength or firmness; lack of vigor; want of resolution or of moral strength; feebleness.

Synonyms:

gap, imperfection, sin, the vapors, help, defenselessness, vulnerability, insubstantiality, defect, indecision, weakliness, taste, virtue, instability, unsubstantiality, preference, epicurean, dereliction, overindulge, disturbance, lapse, inclination, fragileness, invalidity, shortcoming, senility, fun-loving, flaw, delicacy, strength, strong, foible, partiality, fondness, Achilles' heel, femininity, appetite, demerit, asthenia, hunger, wimpishness, helplessness, sybaritic, puniness, bent, wimpiness, extravagance, tendency, relish, good, self-indulgence, flunk, delicateness, dizziness, for fun, want, liking, prostration, decadence, lowness, better, impuissance, enervation, enfeeblement, languidness, unsoundness, like, weak point, vice, indulgence, languor, failing, wishy-washiness, deficiency, fault

inability, handicap, inadequacy, incapability, incompetence, disability

impulsiveness, vacillation, changeability, insipidity, indecisiveness, unsureness, hesitance, double-mindedness, uncertainty, ambivalence, spinelessness, irresolution, shyness, capriciousness, yellowness, volatility, tentativeness, wateriness, shiftiness, halfheartedness, fickleness, unwillingness, inconsistency

debilitation, sickliness, feebleness, infirmity, flimsiness, fragility, softness, powerlessness, frailness, ricketiness, ailment, decrepitude, faintness

mildness, banality, tastelessness, plainness, staleness, unsavoriness, blandness, flatness, vapidity

drowsiness, depression, sleepiness, listlessness, footsoreness, blues, exhaustion, apathy, droopiness, ennui, tiredness, flaccidity, fatigue, boredom, weariness, over-weariness, tedium, cheerlessness

debility, anemia, impotence, frailty

Usage examples:

• I know Fred, I know his weakness. - "Bedside Manner", William Morrison.
• Everybody had been so used to Bess's weakness, and they thought that the end would be a great relief. - "In Wild Rose Time", Amanda M. Douglas.
• What the common people of society think about strength and weakness, is poor stuff, like the rest of their wisdom. - "Donal Grant", George MacDonald.