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Definition of slough : 1. A place of deep mud or mire; a hole full of mire.
2. A wet place; a swale; a side channel or inlet from a river.
3. imp. of Slee, to slay. Slew.
4. Slow.
5. The dead mass separating from a foul sore; the dead part which separates from the living tissue in mortification.
6. The skin, commonly the cast- off skin, of a serpent or of some similar animal.
7. To cast off; to discard as refuse.
8. To form a slough; to separate in the form of dead matter from the living tissues; - often used with off, or away; as, a sloughing ulcer; the dead tissues slough off slowly.

Synonyms:

throw away, marshland, pour forth, molt, spill, swamp, disgorge, morass, necrosis, sphacelus, cast, marsh, drop, mortification, moult, swampland, throw off, shed, fen, quag, bog, quagmire, dry, cast off, throw, shake off, wetland, exuviate, muskeg, mire, gangrene

Usage examples:

• The Bristol road once left, his theory was at fault; he had no clue, and felt, where time was life and more than life, the slough of horrible conjecture rise to his very lips. - "The Castle Inn", Stanley John Weyman.
• It is hard to rescue a man from the slough of luxury and idleness combined. - "Ayala's Angel", Anthony Trollope.
• Other lines began to slough off from the column, swinging east and west, and the crackling became continuous. - "The King in Yellow", Robert W. Chambers.