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Definition of bitter : 1. AA turn of the cable which is round the bitts.
2. Any substance that is bitter. See Bitters.
3. Causing pain or smart; piercing; painful; sharp; severe; as, a bitter cold day.
4. Causing, or fitted to cause, pain or distress to the mind; calamitous; poignant.
5. Characterized by sharpness, severity, or cruelty; harsh; stern; virulent; as, bitter reproach.
6. Having a peculiar, acrid, biting taste, like that of wormwood or an infusion of hops; as, a bitter medicine; bitter as aloes.
7. Mournful; sad; distressing; painful; pitiable.
8. To make bitter.

Synonyms:

rancor, red-hot, sultry, acidulated, bitingly, erosive, jaundice, comfort, tartness, bitterness, acerbity, angry, unpalatable, unfriendly, attitude, like, blistery, hard, acidulous, deadly, astringent, brutal, barbed, taste, rancour, nipping, gall, acerb, stifling, vitriolic, distasteful, vinegarish, harsh, sorrowful, tasteful, intense, acetous, irate, sarcastic, cynical, sulphurous, acidulent, savage, thorniness, mordant, love, sulfurous, blistering, indigestible, rough, mordacious, hot, bitterly, shrilly, intolerable, acrimony, resentment, piercingly

poignant, acrid, tangy, spicy

hateful, venomous, black-hearted, malicious, ill-natured, sullen, foul, catty, sinister, baleful, perfidious, malignant, nasty, baneful, wicked, vicious, rancorous, virulent, mean, evil, corrosive, treacherous, hostile

hurt, offended, resentful, embittered, malevolent, vindictive, spleenful, envious, discontent, piqued, vexed, galled, infuriated, antagonistic, huffed, splenetic, sore, stung, miffed, irritated

piquant, sharp, unripe, pungent, acidic

bitchy, touchy, acerbic, bearish, spiteful, cross, irascible, caustic, prickly, crabbed, snappish, bellicose, crusty, cantankerous, acid, irritable, huffy, petty, petulant, sour, peevish, churlish, surly, acrimonious, cranky, tart

distressful, troublesome, hurtful, smarting, harrowing, anguishing, cutting, grievous, chafing, uncomfortable, stinging, annoying, bothersome, burdensome, trying, irritating, oppressive, cramping, gnawing, grueling, inflaming, withering, biting, offensive, painful, disturbing, torturing, severe, tormenting, crushing, aching, arduous, stabbing, irksome, unbearable, piercing, throbbing, galling, unpleasant, cruel, besetting, aggravating, excruciating, horrendous, insufferable, odious, miserable, wrenching, agonizing, disagreeable, woeful, acute

frosty, chilly, icy, frozen, ice-like, nippy, cold, frigid, wintry

Usage examples:

• It was a horrible, bitter night. - "Harvest", Mrs. Humphry Ward.
• Bitter was the realization to Tharn who, until now, had been certain nothing could prevent his men from taking Sephar. - "Warrior of the Dawn", Howard Carleton Browne.
• William, bitter with disappointment, snapped: What do you mean? - "In a Little Town", Rupert Hughes.